The labyrinth of nuclear reprogramming
نویسندگان
چکیده
منابع مشابه
The labyrinth of nuclear reprogramming.
One of the current chief goals of regenerative medicine involves finding a way to overcome the lack of efficient treatments for thousands of diseases. Recently, increasing evidence indicates that genetic defects observed in patient somatic cells could be erased and/or alleviated by direct reprogramming toward pluripotency and recapitulated upon directed differentiation to specific cell lineages...
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Somatic cell nuclear transfer (SCNT or cloning) returns a differentiated cell to a totipotent status; a process termed nuclear reprogramming. Reproductive cloning has potential applications in both agriculture and biomedicine, but is limited by low efficiency. To understand the deficiencies of nuclear reprogramming, our research has focused on both candidate genes and global gene expression pat...
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William Walker is professor of international relations at the University of St. Andrews in Scotland. He is the co-author with David Albright and Frans Berkhout of SIPRI’s Plutonium and Highly Enriched Uranium: World Inventories, Capabilities and Policies (forthcoming, 1996). There have been many recent cases of states reversing course. Russia has embraced capitalism and democracy, China has thr...
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There is currently particular interest in the field of nuclear reprogramming, a process by which the identity of specialised cells may be changed, typically to an embryonic-like state. Reprogramming procedures provide insight into many mechanisms of fundamental cell biology and have several promising applications, most notably in healthcare through the development of human disease models and pa...
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Embryonic stem cells are promising donor cell sources for cell transplantation therapy, which may in the future be used to treat various diseases and injuries. However, as is the case for organ transplantation, immune rejection after transplantation is a potential problem with this type of therapy. Moreover, the use of human embryos presents serious ethical difficulties. These issues may be ove...
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ژورنال
عنوان ژورنال: Journal of Molecular Cell Biology
سال: 2011
ISSN: 1674-2788
DOI: 10.1093/jmcb/mjr031